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前列腺穿刺存在漏诊前列腺癌的可能，重复穿刺有其必要性。本文对前列腺重复穿刺独立危险因素、穿刺途径选择和穿刺新技术进展方面进行综述，以提高临床医生对前列腺重复穿刺适应证的认识。对符合前列腺重复穿刺的患者，推荐使用mpMRI靶向穿刺，以提高有临床意义前列腺癌的检出率，减少无临床意义前列腺癌的检出率。“,”Repeat prostate biopsy is of great significance for missed diagnosis of prostate cancer. We make a review on the independent risk factors, route selection and new techniques to improve clinicans’ cognition of prostate biopsy indications. MpMRI targeted biopsy is recommended for patients who are eligibile for repeat biopsy for higher detection rate of clinically significant prostate cancer and lower rate of non-clinically significant prostate cancer.