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目的探讨妊娠合并子宫颈上皮内瘤变患者高危型人乳头状瘤病毒(HPV)感染情况。方法将2011年11月至2012年10月间收治的118例妊娠合并子宫颈上皮内瘤变患者(实验组)和118例宫颈健康的妊娠女性(对照组)作为研究对象,比较两组高危型HPV的感染情况。结果妊娠合并宫颈上皮内瘤变(CIN)患者感染的HPV主要类型为HPV16和HPV18,两者在宫颈癌发生发展中可能起重要作用,宫颈病变的级别与HPV的阳性率和载荷量呈显著正相关,两者可以作为妊娠合并CIN患者早期诊断的临床指标之一。结论妊娠合并子宫颈上皮内瘤变患者的高危型HPV感染可以作为诊断宫颈癌的重要要指标,值得临床大力推广。
Objective To investigate the high risk human papilloma virus (HPV) infection in patients with pregnancy complicated with cervical intraepithelial neoplasia. Methods A total of 118 pregnant women with cervical intraepithelial neoplasia (experimental group) and 118 healthy pregnant women (control group) who were treated between November 2011 and October 2012 were enrolled in this study. The risk factors of high risk type HPV infection. Results The main types of HPV infection in patients with pregnancy complicated with cervical intraepithelial neoplasia (CIN) were HPV16 and HPV18, both of which may play an important role in the development of cervical cancer. The grade of cervical lesions and HPV positive rate and load were significantly positive Which can be used as one of the clinical indicators of early diagnosis of CIN in pregnancy. Conclusions High-risk HPV infection in patients with cervical intraepithelial neoplasia complicated with pregnancy can be an important index for diagnosis of cervical cancer and is worthy of clinical promotion.