在韩国,干侧柏叶(Biota orientalis)被用作止血剂、祛痰剂和降压剂。据报道,其中含有一些类黄酮、萜烯和酚类化合物。在寻找对抗谷氨酸诱导神经毒性的天然产物的研究中,发现侧柏叶90％甲醇组分具有显著神经保护活性,以生物活性为指导,从中分离得到1个新的松脂衍生物(1)、1个新的异海松脂烷二萜(2)和3个已知的二萜化合物(3～5)。 干燥侧柏叶(9kg)用80％甲醇超声提取3次,真空干燥得到80％甲醇提物(830g)。将80％甲醇提取物混悬于蒸馏水中,用二氯甲烷萃取,二氯甲烷 In South Korea, Biota orientalis is used as a hemostatic agent, an expectorant and a hypotensive agent. According to reports, it contains some flavonoids, terpenes, and phenolic compounds. In the search for natural products against glutamate-induced neurotoxicity, it was found that 90% methanol components of Platycladus orientalis leaves have significant neuroprotective activity, and a new oleoresin derivative was isolated from it, under the guidance of biological activity (1) , a new iso-hairmarane dioxime (2) and three known diterpene compounds (3 to 5). The dried oriental arborvitae leaves (9 kg) were ultrasonically extracted with 80% methanol 3 times and vacuum dried to give 80% methanol extract (830 g). The 80% methanol extract was suspended in distilled water and extracted with dichloromethane, dichloromethane