目的探讨围绝经期女性睡眠模式与骨密度的关系。方法对南京6510例40岁以上女性进行问卷调查和跟骨定量超声测量骨密度,分析睡眠模式与骨密度的关系。结果 6510例受试对象中,50.01%诊断为骨量正常;36.51%诊断为骨量减少;12.47%诊断为骨质疏松。与未绝经女性相比,已绝经女性更容易发生骨量减少和骨质疏松(P<0.01)。在校正了相关影响因素后,入睡时间在24点以后女性的骨量减少和骨质疏松发生风险是22~23点入睡女性的2.183倍和1.687倍(P<0.05)。日睡眠总时间>10h和夜间睡眠时间<7h的女性发生骨量减少和骨质疏松的风险更高(P<0.05)。相比白天不睡和不午睡的女性,白天睡眠时间>120min和午睡时间>30min的女性发生骨量减少和骨质疏松的风险升高(P<0.05)。结论睡眠的生理节律打乱可能促进绝经女性的骨量流失。 Objective To investigate the relationship between sleep patterns and bone mineral density in perimenopausal women. Methods 6510 cases of women over 40 years old in Nanjing were surveyed by questionnaire and the bone mineral density was measured by quantitative ultrasound. The relationship between sleep pattern and bone mineral density was analyzed. Results Of 6510 subjects, 50.01% were diagnosed as normal bone mass, 36.51% were diagnosed as osteopenia, and 12.47% were diagnosed as osteoporosis. Compared with non-menopausal women, menopausal women are more prone to osteopenia and osteoporosis (P <0.01). After adjusting for the relevant factors, the risk of osteopenia and osteoporosis in women after going to sleep at 24 o’clock was 2.183-fold and 1.687-fold (P <0.05) higher than those who fell asleep at 22 to 23 o’clock. Women who had a total daily sleep time of> 10 hours and a nighttime sleep time of <7 hours had a higher risk of osteopenia and osteoporosis (P <0.05). Compared to women who did not sleep and did not nap during the daytime, women with increased daytime sleepiness> 120 minutes and nap> 30 minutes had an increased risk of osteopenia and osteoporosis (P <0.05). Conclusion Disruption of circadian rhythm of sleep may promote bone loss in postmenopausal women.