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2型黄斑毛细血管扩张症(MacTel type 2)是以黄斑颞侧毛细血管网扩张及视网膜神经上皮层萎缩为特征的一类疾病,多于50 ～ 60岁起病,同时累及双眼.此病的发病机制一直是争论的焦点,主要集中在此病的起源是血管病变还是神经上皮病变.近年来,随着各种新兴影像学检查,如光相干断层扫描(OCT)、光相干断层扫描血流成像(OCTA)、视网膜色素显像等的出现,为该病发病机制的探究提供了有效的工具;同时随着基因组学的发展,让我们能够从基因位点的层面加深对这一疾病的认识,为下一步的研究指出了新的方向.本文就MacTel分类的变迁、FFA表现和组织病理学特征以及近年来出现的OCT、OCTA、视网膜色素显像、基因组学等方面的研究做简要综述.“,”Macular telangiectasia type 2 (MacTel type 2) is a kind of disease that characterized by the dilation of capillary in temporal macula lutea and the degeneration of neurosensory retina.It usually affects both eyes in patient aged 50 to 60.The pathophysiology of MacTel type 2 was not understood very well.With the rapid development of imaging technic and the genomic research,we have illuminated some secrets of this disease.In this article,the development of classification,fundus fluorescein angiography (FFA) and histology feature,and the characteristic of optical coherence tomography (OCT),optical coherence tomographic angiography (OCTA),macular pigment,genome about MacTel type 2 were reviewed.