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SELDI- TOF- MS是一种应用特殊的增强表面或芯片结合激光解吸离子化飞行时间质谱分析样品中蛋白质的技术,具有微量、快速、高通量等特点,尤其适于分析低分子量、低丰度的蛋白质。肿瘤血清蛋白质组研究是利用SELDI- TOF- MS技术分析血清中蛋白质成分的动态变化,以获得肿瘤特异性相关蛋白。在多种癌症研究中,SEL- DI -TOF MS均显示出对肿瘤的早期诊断、分级分类及人群筛查具有良好的应用前景。
SELDI-TOF-MS is a technology that uses special surface-enhanced or chip-coupled laser desorption ionization time of flight mass spectrometry to analyze proteins in samples with trace, rapid, high throughput and is especially suitable for analyzing low molecular weight, low abundance Degree of protein. Tumor serum proteome research is the use of SELDI-TOF-MS technology to analyze the dynamic changes of protein components in serum to obtain tumor-specific protein. In various cancer studies, SEL-DI-TOF MS has shown promising applications in the early diagnosis, classification and population screening of tumors.