【摘 要】
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Developing low toxicity and multifunctional theranostic nanoplatform is the key for precise cancer diagnosis and treatment.Herein,an inorganic-organic hybrid nanocomposite is designed by modifying zirconium dioxide (ZrO2) with polydopamine (PDA) followed
【机 构】
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Laboratory for Micro-sized Functional Materials,Department of Chemistry and College of Elementary Ed
论文部分内容阅读
Developing low toxicity and multifunctional theranostic nanoplatform is the key for precise cancer diagnosis and treatment.Herein,an inorganic-organic hybrid nanocomposite is designed by modifying zirconium dioxide (ZrO2) with polydopamine (PDA) followed by doping Mn2+ ions and functionalizing with Tween 20 (Tween-ZrO2@PDA-Mn2+) for multimodal imaging and chemo-photothermal combina-tion therapy.The as-prepared nanocomposite exhibits good biocompatibility in vitro and in vivo.Specifically,it can be employed as a multifunctional platform not only for computed tomography (CT)imaging and T1-weighted magnetic resonance (MR) imaging,but also for efficient chemotherapeutic drug doxorubicin hydrochloride (DOX) loading.Importantly,because of the pronounced photothermal conversion performance and controllable DOX release ability triggered by the near-infrared (NIR)irradiation and acidic pH,the synergistic effect between photothermal therapy and chemotherapy results in an enhanced cancer treatment efficacy in vivo.Our work provides a high-performance inorganic-organic hybrid nanotheranostic platform for chemo-photothermal cancer therapy guided by CT and MR imaging.
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