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目的研究阿托伐他汀联合卡托普利对高血压患者颈动脉内膜中层厚度(IMT)及高敏C反应蛋白(hsCRP)的影响。方法收集高血压患者88例,随机均分为两组:对照组患者采取卡托普利片单独给药治疗,每日1次,每次1片,疗程为6个月;试验组患者在对照组的基础上加服阿托伐他汀片,每日1次,每次1片,疗程为6个月。观察两组患者治疗前和治疗6个月后SBP、DBP、颈动脉IMT、血清hsCRP及血脂水平等变化。结果治疗6个月后,两组SBP、DBP、颈动脉IMT、血清hsCRP、TC、LDL-C水平均较治疗前改善(P<0.05),且观察组上述指标均低于对照组(P<0.05)。结论阿托伐他汀联合卡托普利治疗更能有效控制血压、调节血脂,同时可以改善颈动脉IMT、抑制炎症反应。
Objective To investigate the effects of atorvastatin combined with captopril on carotid intima-media thickness (IMT) and high-sensitivity C-reactive protein (hsCRP) in patients with essential hypertension. Methods 88 patients with hypertension were randomly divided into two groups: patients in the control group were treated with captopril alone, once daily for 6 months. In the control group, patients in the control group Based on the group plus atorvastatin tablets, 1 day, each 1, treatment for 6 months. The changes of SBP, DBP, carotid IMT, serum hsCRP and blood lipid levels were observed before treatment and 6 months after treatment in both groups. Results The levels of SBP, DBP, carotid artery IMT, serum hsCRP, TC and LDL-C in both groups were improved 6 months after treatment (P <0.05), and the above indexes in the observation group were lower than those in the control group (P < 0.05). Conclusion Atorvastatin combined with captopril treatment can effectively control blood pressure, regulate blood fat, at the same time can improve the carotid artery IMT, inhibit the inflammatory response.