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1964年,Thurau提出了肾小球血液动力学调节是由肾单位本身完成的学说。1970年,Schnermann首先用肾单位微灌流法显示:远曲小管逆流注入较高浓度的NaCl液引起所属肾小球的滤过率下降,从而确立了管球反馈理论。至今,许多国家的科学家对肾单位管球反馈问题进行了广泛深入的研究,不仅加深了人们对肾单位结构和功能的认识,而且有助于加深对肾脏的病理、药理以及临床的理解。
In 1964 Thurau proposed that the regulation of glomerular hemodynamics is done by the nephron itself. In 1970, Schnermann first used the nephron micro-perfusion method to show that the retrograde flow of far convoluted tubules into the higher concentration of NaCl solution caused the filtration rate of the glomerulus to decrease, thus establishing the tube ball feedback theory. So far, scientists from many countries have carried out extensive and in-depth research on the neutron tube ball feedback problem, which not only deepens people’s understanding of the structure and function of the nephron, but also helps to deepen the pathology, pharmacology and clinical understanding of the kidney.