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生长介质(Somatomedins,SM)的定义是von WYK和Underwood于1978年提出的。生长介质须具备下列标准:(1)对生长激素(GH)有依赖性;(2)在软骨中有促进硫酸和软骨素的结合作用;(3)在骨骼以外的组织中有类似胰岛素的作用;(4)能刺激脱氧核糖核酸(DNA)的合成和细胞的增殖。按此标准生长介质包括以下物质(皆
The definition of Somatomedins (SM) was proposed by von WYK and Underwood in 1978. The growth media must meet the following criteria: (1) dependence on growth hormone (GH); (2) promotion of the binding of sulfate and chondroitin to cartilage; and (3) insulin-like effects in tissues other than bone ; (4) can stimulate the synthesis of DNA and cell proliferation. According to this standard growth medium includes the following substances (all