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目的:探讨质子泵抑制剂雷贝拉唑结合氟哌噻吨/美利曲辛(黛力新)治疗非糜烂性反流病(NERD)的临床疗效。方法:选择109例非糜烂性反流病伴抑郁、焦虑患者并随机分为2组,A组57例,给予雷贝拉唑20mg,早、晚餐前各1次,氟哌噻吨/美利曲辛10.5mg,早、中餐后各1次;B组52例,给予雷贝拉唑20mg,早、中餐前各1次,两组疗程均为6周,疗程结束后通过症状记分,判断疗效。结果:治疗6周后,两组患者的烧心、胸痛、反酸等主要症状的积分比较,差异均有统计学意义;A组显效率为86.5%,总有效率为96.1%;B组显效率为67.3%,总有效率为82.3%。两组比较差异有显著性(P<0.05)。结论:对伴有抑郁、焦虑的NERD患者,雷贝拉唑结合氟哌噻吨/美利曲辛治疗是有效的治疗方案之一。
Objective: To investigate the clinical efficacy of proton pump inhibitor rabeprazole combined with flupentixol / melitracen (Deanxit) in the treatment of non-erosive reflux disease (NERD). Methods: A total of 109 patients with non-erosive reflux disease with depression and anxiety were randomly divided into two groups. 57 patients in group A received rabeprazole 20mg once daily before and after dinner, Xuanxin 10.5mg, as early as before and after the Chinese meal 1; B group 52 cases, given rabeprazole 20mg, as early as before each meal before 1, two courses of treatment were 6 weeks after treatment by symptom score to determine the efficacy . Results: After 6 weeks of treatment, the scores of heartburn, chest pain, acid reflux and other major symptoms in two groups were statistically significant. The effective rate was 86.5% in group A, and the total effective rate was 96.1% 67.3%, the total effective rate was 82.3%. There was significant difference between the two groups (P <0.05). Conclusion: Rabeprazole combined with flupentixol / melitracin is an effective treatment for NERD patients with depression and anxiety.