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目的:探讨125I粒子组织间植入治疗局部进展期胰腺癌的疗效。方法:选择局部进展期胰腺癌无法行根治手术患者42例,术中植入125I粒子及姑息性手术。结果:术后患者顽固性疼痛症状明显缓解(P<0.05),Karnofsky评分显著提高(P<0.05),无明显骨髓抑制及免疫抑制。3个月、6个月、12个月生存率分别为100%、76.7%、33.3%。其中Ⅱ期6个月、12个月生存率为90.0%、55.5%,Ⅲ期6、12个月生存率为68.2%、13.6%(P<0.05)。结论:125I组织间放射治疗局部进展期胰腺癌,方法简单、安全,能较好改善疾病相关症状,近期疗效确切,是治疗局部进展期胰腺癌较理想的方法之一。
Objective: To investigate the therapeutic effect of 125I seed implantation in the treatment of locally advanced pancreatic cancer. Methods: Forty-two patients with locally advanced pancreatic cancer who were unable to undergo radical surgery were enrolled. 125I seeds and palliative surgery were implanted. Results: The postoperative refractory pain symptoms were relieved (P <0.05), Karnofsky score was significantly increased (P <0.05), and no obvious myelosuppression and immunosuppression. The survival rates at 3 months, 6 months and 12 months were 100%, 76.7% and 33.3%, respectively. The survival rates at 6 months and 12 months were 90.0% and 55.5% respectively. The 6 and 12 months survival rates were 68.2% and 13.6%, respectively (P <0.05). CONCLUSION: Radiotherapy of locally advanced pancreatic cancer with 125I tissue is simple and safe, and it can improve disease-related symptoms. The recent curative effect is definite. It is one of the ideal methods for the treatment of locally advanced pancreatic cancer.