As each type of satellite network has different link features, its data transmission must be designed based on its link features to improve the efficiency of data transferring. The transmission of navigation integrated services information(NISI)in a global navigation satellite system(GNSS) with inter-satellite links(ISLs) is studied by taking the real situation of inter-satellite communication links into account. An on-demand computing and buffering centralized route strategy is proposed based on dynamic grouping and the topology evolution law of the GNSS network within which the satellite nodes are operated in the manner of dynamic grouping. Dynamic grouping is based on satellites spatial relationships and the group role of the satellite node changes by turns due to its spatial relationships. The route strategy provides significant advantages of high efficiency, low complexity, and flexible configuration, by which the established GNSS can possess the features and capabilities of feasible deployment, efficient transmission, convenient management, structural invulnerability and flexible expansion. The transmission of navigation integrated bespoke information (NISI) in a global navigation satellite system (GNSS) with inter-satellite links (ISLs) is studied by taking the real situation of inter-satellite communication links into account. An on-demand computing and buffering centralized route strategy is proposed based on dynamic grouping and the topology evolution law of the GNSS network within which the satellite nodes are operated in the manner of dynamic grouping. Dynamic grouping is based on satellites spatial relationships and the group role of the satellite node changes by turns due to its spatial relationships. The route strategy provides significant advantages of high efficiency, low complexity, and flexible configuration, by which the established GNSS can posse the features and capabilities of feasi ble deployment, efficient transmission, convenient management, structural invulnerability and flexible expansion.