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目的探讨人工肝支持系统在治疗药物性肝病中的应用价值。方法对25例药物所致肝功能损害的患者在内科治疗基础上采用人工肝(血液灌流、血液滤过及血浆置换)治疗,对治疗前后肝功能进行比较。结果 25例患者中治愈好转19例,死亡6例,有效率76%,治疗前后患者丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆汁酸(TBA)、总胆红素(TBIL)比较均有显著性差异。结论人工肝支持系统可有效治疗药物性肝病。
Objective To investigate the value of artificial liver support system in the treatment of drug-induced liver disease. Methods 25 patients with liver dysfunction induced by drugs were treated with artificial liver (hemoperfusion, hemofiltration and plasma exchange) on the basis of medical treatment, and the liver function was compared before and after treatment. Results Among the 25 patients, 19 cases were cured and 6 cases died. The effective rate was 76%. The levels of ALT, AST, TBA, Total bilirubin (TBIL) were significantly different. Conclusion Artificial liver support system can effectively treat drug-induced liver disease.