【摘 要】
：
AIM: Evidence has accumulated to indicate the importance ofsubstance P in the emetic reflex. The present investigations weredesigned to charaterize tachykinin
【机 构】
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Department of Pharmacology, Faculty of Medicine, The Chinese Univervity of Hong Kong, Shatin, N T, H
【出 处】
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Acta Pharmacologica Sinica
论文部分内容阅读
AIM: Evidence has accumulated to indicate the importance ofsubstance P in the emetic reflex. The present investigations weredesigned to charaterize tachykinin NK_1 receptors in the emeticreflex of Suncus murinus. METHODS: Several antagonistswere assessed for a potential to inhibit nicotine (5 mg·kg~(-1),sc)-, copper sulphate pentahydrate (120 mg·kg~(-1) ig)-, andmotion (4 cm lateral displacement at 1 Hz)-induced emesis.RESULTS: CP 122 721, CP-99 994,RP 67 580, and FK 888
AIM: Evidence has accumulated to indicate the importance ofsubstance P in the emetic reflex. The present investigations were designed to charaterize tachykinin NK_1 receptors in the emeticreflex of Suncus murinus. METHODS: Several antagonistswere assessed for a potential to inhibit nicotine (5 mg · kg ~ ( -1), sc) -, copper sulphate pentahydrate (120 mg · kg -1) ig), andmotion (4 cm lateral displacement at 1 Hz) -induced emesis.RESULTS: CP 122 721, CP- 99 994, RP 67 580, and FK 888
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