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目的探讨高敏C-反应蛋白(hs-CRP)与冠状动脉病变程度的相关性。方法测定40例稳定性心绞痛患者(SAP组)、50例不稳定心绞痛患者(UAP组)、30例急性心肌梗死患者(AMI组)及60例健康者(对照组)的hs-CRP及心肌肌钙蛋白Ⅰ(cTnI)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)等心肌标志物水平。结果 hs-CRP水平在对照组、SAP组、UAP组和AMI组分别为(2.3±0.5)mg/L、(4.2±0.6)mg/L、(6.4±1.0)mg/L、(14.7±2.9)mg/L,各组间存在显著递增趋势,即AMI组>UAP组>SAP组>对照组。而cTnI仅UAP组和AMI显著升高,CK和CK-MB仅在AMI组显著升高。结论 hs-CRP水平与冠状动脉病变程度密切相关。
Objective To investigate the correlation between high sensitivity C-reactive protein (hs-CRP) and coronary artery lesion. Methods The hs-CRP and cardiac muscle of 40 patients with stable angina (SAP group), 50 patients with unstable angina pectoris (UAP group), 30 patients with acute myocardial infarction (AMI group) and 60 healthy controls (control group) Cardiac troponin I (cTnI), creatine kinase (CK), creatine kinase (CK-MB) and other cardiac markers. Results The levels of hs-CRP in the control group, SAP group, UAP group and AMI group were (2.3 ± 0.5) mg / L, (4.2 ± 0.6) mg / L and ) mg / L, there was a significant increasing trend among all groups, namely AMI group> UAP group> SAP group> control group. The cTnI only UAP group and AMI significantly increased, CK and CK-MB only in the AMI group was significantly higher. Conclusion The level of hs-CRP is closely related to the degree of coronary artery disease.