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目的探讨慢性前列腺炎患者前列腺液中病原菌菌种的临床分布及耐药性,为临床合理治疗提供依据。方法收集2007年1月至2008年12月慢性前列腺炎患者的前列腺液标本进行培养、鉴定和药物敏感试验,并对所得结果进行统计分析。结果385例患者的前列腺液标本中,培养出革兰阳性菌55株,占73.3%,其中又以溶血葡萄球菌为主,检测出34株,占45.3%;在检测出的45株葡萄球菌中,MRS36株,占80%。革兰阴性菌20株,占26.7%,其中又以大肠埃希菌为主,检测出9株,占12%;在15株大肠埃希菌和肺炎克雷伯菌中,检测出产ESBLs株3株,大肠埃希菌产酶率为22.2%。革兰阳性球菌对青霉素G的耐药率达到90%以上,对万古霉素敏感,未发现耐药株;革兰阴性杆菌对氨苄西林的耐药率达85%以上,对美洛培南和亚胺培南敏感,耐药率低于10%。结论对细菌性前列腺炎的治疗关键是在正确的病原学诊断和药物敏感试验指导下合理使用抗菌素。
Objective To investigate the clinical distribution and drug resistance of pathogenic bacteria in prostatic fluid in patients with chronic prostatitis and provide basis for clinical rational treatment. Methods Prostate fluid specimens from patients with chronic prostatitis from January 2007 to December 2008 were collected for culture, identification and drug susceptibility testing, and the results were statistically analyzed. Results Among the 385 prostatic fluid specimens, 55 strains of Gram-positive bacteria were cultivated, accounting for 73.3% of whom were predominantly Staphylococcus hemolyticus; 34 strains were detected (45.3%); of the 45 staphylococci tested, , MRS36 strains, accounting for 80%. Gram-negative bacteria 20 strains, accounting for 26.7%, of which Escherichia coli-based, detected 9 strains, accounting for 12%; in 15 strains of Escherichia coli and Klebsiella pneumoniae, the detection of ESBLs producing strains 3 Strain, Escherichia coli production rate was 22.2%. Gram-positive cocci penicillin G resistance rate of 90% or more, sensitive to vancomycin, no drug-resistant strains; Gram-negative bacilli ampicillin resistance rate of 85% or more, meropenem and Imipenem sensitive, resistance rate of less than 10%. Conclusion The key to the treatment of bacterial prostatitis is the rational use of antibiotics under the guidance of proper pathogenic diagnosis and drug sensitivity test.