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目的探讨轮状病毒、人类杯状病毒引起的感染性腹泻婴幼儿心肌酶及心电图的变化。方法选择卢龙县医院2006年10月—2008年3月收治的256例感染性腹泻住院患儿的粪便标本和空腹血清,检测轮状病毒、人类杯状病毒和心肌酶活性,并检查心电图。结果轮状病毒和人类杯状病毒导致的腹泻患儿谷氨酸氨基转移酶、乳酸脱氢酶、磷酸肌酸激酶和肌酸激酶同工酶的水平间差异无统计学意义(P<0.05),但均明显高于病毒检测阴性的腹泻患儿(P<0.05)。心肌酶水平增高患儿中部分心电图可有变化,极少发生心律失常和心功能不全。结论轮状病毒和人类杯状病毒感染引起的婴幼儿腹泻,可引发不同程度的心肌损害,两种病毒对心肌酶的影响无明显差异;这种病理变化是否为导致婴幼儿死亡的一种因素,需进一步探讨。
Objective To investigate the changes of myocardial enzymes and electrocardiogram in infants with rotavirus and human calicivirus induced diarrhea. Methods Totally 256 stool samples and fasting serum from hospitalized children with infectious diarrhea admitted to Lulong County Hospital from October 2006 to March 2008 were collected. The rotavirus, human calicheaviruses and myocardial enzymes were detected and the electrocardiogram was examined. Results There was no significant difference in the levels of glutamate aminotransferase, lactate dehydrogenase, creatine phosphokinase and creatine kinase among children with diarrhea caused by rotavirus and human calicivirus (P <0.05) , But both were significantly higher than those of children with negative diarrhea (P <0.05). Increased levels of myocardial enzymes in children with some changes in ECG, rare arrhythmia and cardiac insufficiency. Conclusions Infants and young children’s diarrhea caused by rotavirus and human calicivirus can cause different degrees of myocardial damage. There is no significant difference between the two viruses on myocardial enzymes. Whether this pathological change is a factor leading to the death of infants and young children , Need to be further explored.