目的　报道低体重婴儿室间隔缺损 (VSD)伴肺动脉高压的外科手术修补结果和体会。方法　 1994年 3月至 1999年 12月 ,对 5 0例 2～ 11月龄 ,体重 3 2～ 5 0kg的VSD病婴采用中度低温体外循环行补片修补术。全组术前均伴中度以上肺动脉高压 (Pp/Ps平均为 0 6 8± 0 0 9)。结果　住院死亡 2例 ,住院死亡率为 4% ,死亡原因分别为心包压塞和脑昏迷。术后主要并发症为肺部感染、肺动脉高压危象和心律失常。结论　对 5kg以下低体重婴儿的较大VSD采用外科手术修补可以取得满意效果 Objective To report the results and experience of surgical repair of low birth weight infant ventricular septal defect (VSD) with pulmonary hypertension. Methods From March 1994 to December 1999, 50 cases of VSD infants aged 2 ~ 11 months and weighing 32 ~ 50 kg were treated with patch-replacement with mild hypothermia cardiopulmonary bypass. All patients with moderate or severe pulmonary hypertension (Pp / Ps average of 0 6 8 ± 0 0 9). Results Two cases were hospitalized and the in-hospital mortality was 4%. The causes of death were pericardial tamponade and cerebral coma. The main postoperative complications were pulmonary infection, pulmonary hypertension crisis and arrhythmia. Conclusion Satisfactory results can be achieved by surgical repair of larger VSD in infants weighing less than 5kg