氨茶碱涂膜剂为一种新颖的骨架型经皮给药系统。采用离体鼠皮进行该涂膜剂的体外渗透试验，并用组胺－乙酰胆碱引喘试验考察其平喘作用。结果表明，涂膜剂中氨茶碱以零级动力学经皮吸收；０～１２ｈ累积渗透量为４０．４％，渗透速率７７．６８μｇ／ｃｍ２·ｈ，本品有显著平喘作用，其作用优于氨茶碱溶液剂。 Aminophylline coating agent is a novel skeleton transdermal drug delivery system. The in vitro rat skin was used for the in vitro penetration test of the film-coating agent. The histamine-acetylcholine-induced asthma test was used to investigate the antiasthmatic effect. The results showed that aminophylline was percutaneously absorbed by zero-order kinetics. The cumulative permeation of 0-12h was 40.4% and the permeation rate was 77.68μg / cm2 · h. The effect is better than aminophylline solution.