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目的 探讨坤泰胶囊治疗在体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)中卵巢低反应(poor ovarian response,POR)患者的临床效果.方法 90例均为2015年4月-2016年4月在山东省潍坊市人民医院生殖医学科就诊的卵巢储备功能减退(diminished ovarian reserve,DOR)的不孕症患者.均采用常规微刺激方案,充分知情同意,根据是否同意用药分观察组(48例)和对照组(42例),观察组进入周期前1个月开始口服坤泰胶囊;对照组直接进入周期.观察两组患者年龄、不孕年限、体质量指数(body mass index,BMI)、肾阴虚证候评分、基础卵泡刺激素(basal follicle stimulating hormone,bFSH)、基础促黄体生成素(basal luteinizing hormone,bLH)、基础雌二醇(basal estradiol,bE2)、基础窦卵泡数(antral follicle count,AFC)、抗苗勒管激素(anti-Müllerian hormone,AMH)水平;比较两组IVF过程中促性腺激素(gonadotropin,Gn)应用天数、Gn用量、人绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)扳机日单个成熟卵泡(直径≥14 mm)的E2水平、获卵数、可移植胚胎数、优质胚胎数.结果 两组Gn天数及Gn用量,差异无统计学意义(P＞0.05);观察组HCG日单个成熟卵泡E2水平、获卵数、可移植胚胎数较对照组高(P＜0.05);优胚数亦呈上升趋势,但差异无统计学意义(P＞0.05).结论 坤泰胶囊能提高IVF-ET中POR患者HCG日单个成熟卵泡E2水平,增加获卵数和可移植胚胎数,有助于改善IVF结局.“,”Objective To study the application of Kuntai Capsule (KTC) in poor ovarian response (POR) patients undergoing in vitro fertilization-embryo transfer (IVF-ET).Methods Recruited were 90 diminished ovarian reserve (DOR) infertility patients at Department of Reproductive Medicine,Weifang People's Hospital from April 2015 to April 2016.All patients received routine micro-stimulation protocol and signed informed consent.They were assigned to the observation group (48 cases) and the control group (42 cases) according to whether they would accept treatment protocols.Patients in the observation group took KTC one month earlier before they entered the menstrual cycle,while those in the control group entered the menstrual cycle directly.Age,duration of infertility,body mass index (BMI),scores for Shen yin deficiency syndrome (SYDS),levels of basal follicle stimulating hormone (bFSH) basal luteinizing hormone (bLH),basal estradiol (bE2),and antral follicle count (AFC),anti-Müllerian hormone (AMH) were observed in the two groups.Gonadotropin (Gn) using days,Gn dosage,E2 level in single mature follicle (diameter ≥14 mm) on human chorionic gonadotrophin (HCG) day,the number of oocytes retrieved,portable embryos number,and high quality embryos number were compared during IVF.Results No statistical difference was shown in Gn using days or Gn dosage between the two groups (P ＞0.05).E2 levels in single mature follicle on HCG day,number of oocytes retrieved,and portable embryos number were higher in the observation group than in the control group (P ＜0.05).The high quality embryos number showed increasing tendency,but with no statistical difference between the two grups (P ＞0.05).Conclusion KTC could improve E2 levels in single mature follicle on HCG day,increase number of oocytes retrieved and portable embryos number in POR patients undergoing IVF-ET,thus improving the outcome of IVF.