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目的分析丙戊酸联合拉莫三嗪治疗各型癫痫的疗效及安全性。方法 90例接受癫痫治疗的患者,按照入院时间的不同分为观察组和对照组,各45例。观察组患者给予丙戊酸联合拉莫三嗪治疗,对照组患者给予丙戊酸治疗。比较两组治疗效果。结果观察组完全控制25例、部分控制19例、未控制1例,有效率为97.8%;对照组完全控制19例、部分控制20例、未控制6例,有效率为86.7%,两组有效率比较差异具有统计学意义(P<0.05)。观察组不良反应发生率(6.7%)低于对照组(22.2%),差异具有统计学意义(P<0.05)。结论在对癫痫患者进行治疗的过程中运用丙戊酸联合拉莫三嗪治疗可以提高治疗的效果,具有较好的安全性,是一种较好的治疗药物组合,值得在临床上推广和运用。
Objective To analyze the efficacy and safety of valproic acid plus lamotrigine in the treatment of various types of epilepsy. Methods 90 cases of patients receiving epilepsy were divided into observation group and control group according to the different admission time, 45 cases in each group. Patients in the observation group were treated with valproic acid plus lamotrigine, and patients in the control group were treated with valproic acid. Compare the treatment effect of two groups. Results The observation group was completely controlled in 25 cases, partially controlled in 19 cases and uncontrolled in 1 case. The effective rate was 97.8%. In the control group, 19 cases were completely controlled, 20 partially controlled and 6 uncontrolled. The effective rate was 86.7% The difference in efficiency was statistically significant (P <0.05). The incidence of adverse reactions in the observation group (6.7%) was lower than that in the control group (22.2%), the difference was statistically significant (P <0.05). Conclusion Valproic acid combined with lamotrigine can improve the therapeutic effect in the treatment of patients with epilepsy, has better safety and is a better therapeutic drug combination, so it is worth to be popularized and applied clinically .