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This paper introduces the experimental designs and outputs of the Diagnostic, Evaluation and Characterization of Klima (DECK), historical, Scenario Model Intercomparison Project (MIP), and Paleoclimate MIP (PMIP) experiments from the Nanjing University of Information Science and Technology Earth System Model version 3 (NESM3). Results show that NESM3 reasonably simulates the modern climate and the major internal modes of climate variability. In the Scenario MIP experiment, changes in the projected surface air temperature (SAT) show robust “Northern Hemisphere (NH) warmer than Southern Hemisphere (SH)” and “land warmer than ocean” patterns, as well as an El Ni?o-like warming over the tropical Pacific. Changes in the projected precipitation exhibit “NH wetter than SH” and “eastern hemisphere gets wetter and western hemisphere gets drier” patterns over the tropics. These precipitation patterns are driven by circulation changes owing to the inhomogeneous warming patterns. Two PMIP experiments show enlarged seasonal cycles of SAT and precipitation over the NH due to the seasonal redistribution of solar radiation. Changes in the climatological mean SAT, precipitation, and ENSO amplitudes are consistent with the results from PMIP4 models. The NESM3 outputs are available on the Earth System Grid Federation nodes for data users.