1965年 Snow 报道心得安能降低急性心肌梗塞患者的死亡率。但受试病例较少,且试验方法既非随机又非双盲。虽然该试验的设计在这一点上及其他方面未达到目前所要求的标准,但因为理论上β-阻滞剂确能减弱交感神经对缺血心肌的刺激,所以 Snow 的发现鼓励人们对心肌梗塞后β-阻滞剂的应用作进一步试验。遗憾的是,Snow 的试验结果难以重复。最近挪威对噻吗心安(timolol)的研究似乎重 Snow reports in 1965 that propranolol can reduce mortality in patients with acute myocardial infarction. However, fewer test cases, and the test method is neither random nor double-blind. Although the design of this trial did not meet the current required standards in this and other respects, Snow’s discovery encouraged the discovery of myocardial infarction because theoretically beta-blockers do attenuate sympathetic stimulation of ischemic myocardium Post-beta-blocker application for further testing. Unfortunately, Snow’s test results are difficult to repeat. The recent study of timolol in Norway seems heavy