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目的了解艾滋病(acquired immunodeficiency syndrome,AIDS)患者巨细胞病毒(cytomegalovirus,CMV)感染情况及与CD+4T淋巴细胞、患者年龄、性别等关系。方法对2006年11月—2011年2月上海市公共卫生临床中心收治的处于III~IV期的291例AIDS住院患者经抗逆转录病毒治疗前的血液样本进行CMV检测、CD+4T淋巴细胞计数,分析其与年龄、性别的关系。结果 CMV DNA在AIDS患者中检出阳性率为51.55%,CMV pp65抗原阳性率为19.91%;CMV检出率与患者CD+4T淋巴细胞数量呈负相关(χ2=42.349,P=0.000);男性CMV DNA阳性率为53.82%,女性为38.10%,二者差异有统计学意义(χ2=3.556,P=0.043)。结论低CD+4T淋巴细胞计数AIDS人群中CMV检出率较高,检出率及病毒载量均与CD+4T淋巴细胞计数呈负相关,男性检出率高于女性。
Objective To understand the infection of cytomegalovirus (CMV) in patients with acquired immunodeficiency syndrome (AIDS) and its relationship with CD + 4T lymphocytes, patient age and gender. Methods A total of 291 AIDS inpatients with stage III-IV disease admitted to Shanghai Public Health Clinical Center from November 2006 to February 2011 were tested for CMV by blood samples before antiretroviral treatment. CD + 4T lymphocyte count , Analyze its relationship with age and gender. Results The positive rate of CMV DNA in AIDS patients was 51.55%, the positive rate of CMV pp65 antigen was 19.91%. The detection rate of CMV was negatively correlated with the number of CD + 4T lymphocytes (χ2 = 42.349, P = 0.000) The positive rate of CMV DNA was 53.82%, while that of female was 38.10%. The difference was statistically significant (χ2 = 3.556, P = 0.043). Conclusions The detection rate of CMV in AIDS population with low CD + 4T lymphocyte count is high, and the detection rate and viral load are negatively correlated with the CD + 4T lymphocyte count. The detection rate of male is higher than that of female.