副肿瘤性天疱疮(paraneoplastic pemphigus,PNP)是一种与肿瘤相伴发的自身免疫综合征,以口腔黏膜广泛糜烂,皮肤出现多形性皮损,且并发肿瘤为特征。PNP临床少见,现报道1例PNP伴腹膜后Castleman’s瘤如下。临床资料患者男,58岁。因口腔黏膜及躯干四肢糜烂,结痂3个月余,加重10天,于2009年3月11日入院。患者发病前半年反复5次因“肺炎”住院治疗,曾用“阿奇霉素,氨曲南”等抗生素,给予“左氧氟沙星”时出现少量皮疹。3个月前再因“肺炎”住院治 Paraneoplastic pemphigus (PNP) is an autoimmune syndrome associated with tumors characterized by extensive erosion of the oral mucosa, pleomorphic skin lesions, and concurrent tumors. PNP clinical rare, is reported in 1 case of PNP with retroperitoneal Castleman’s tumor are as follows. Male patient, 58 years old. Due to oral mucosa and torso limbs erosion, scab more than 3 months, increased 10 days, on March 11, 2009 admission. Repeated five times in the first half of the patient’s illness due to “pneumonia” hospitalization, once used “azithromycin, aztreonam” and other antibiotics, given “levofloxacin ” when a small amount of rash. 3 months ago due to “pneumonia” hospitalized