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目的:探讨变应性鼻炎患者血清中IL-17及其受体的表达,及其与血清中总IgE的关系。方法:采用酶联免疫法检测51例健康志愿者(对照组)和37例变应性鼻炎患者(实验组)血清中IL-17,IL-17R及IgE的含量。结果:与对照组相比,变应性鼻炎患者血清IL-17,IL-17R及IgE的含量均明显升高。IL-17与变应性鼻炎患者血清中IgE成正相关(r=0.9678,P<0.05),而IL-17R与IgE无明显相关性。结论:IL-17和IL-17R均参与变应性鼻炎的发病过程,可作为诊断变应性鼻炎的新指标,且降低IL-17的含量有助于变应性鼻炎的临床治疗。
Objective: To investigate the expression of IL-17 and its receptor in serum of patients with allergic rhinitis and its relationship with serum total IgE. Methods: Serum levels of IL-17, IL-17R and IgE in 51 healthy volunteers (control group) and 37 allergic rhinitis patients (experimental group) were detected by enzyme-linked immunosorbent assay. Results: Compared with the control group, the serum IL-17, IL-17R and IgE levels in patients with allergic rhinitis were significantly increased. There was a positive correlation between IL-17 and serum IgE in patients with allergic rhinitis (r = 0.9678, P <0.05), while there was no significant correlation between IL-17R and IgE. Conclusion: Both IL-17 and IL-17R are involved in the pathogenesis of allergic rhinitis, which can be used as a new indicator in the diagnosis of allergic rhinitis. To reduce the content of IL-17 is helpful for the clinical treatment of allergic rhinitis.