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甲型流感是对人类健康和社会稳定构成极大威胁的急性呼吸道传染病,具有极高的发病率和死亡率。由于甲型流感病毒的高变异性和频繁的耐药性,使得新靶点的抗病毒药物的研发显得非常重要。甲型流感病毒的核蛋白高度保守,是一个潜在的抗病毒药物的靶点,国内外已有相关报道。中草药作为祖国的传统医学宝藏,在防治甲流方面也表现出了独特的优势。本文从甲型流感病毒结构与功能出发,阐述甲型流感病毒核蛋白作为抗病毒靶点的研究进展。
Influenza A is an acute respiratory disease that poses a great threat to human health and social stability, with a very high morbidity and mortality rate. Because of the high variability and frequent resistance of influenza A virus, the development of new target anti-viral drugs is very important. Influenza A virus nucleoprotein highly conserved, is a potential target of antiviral drugs, has been reported at home and abroad. As a traditional medical treasure of the motherland, Chinese herbal medicine also shows its unique advantages in preventing and controlling A-flow. This article from the structure and function of influenza A virus, elaborated the research progress of influenza A virus nucleoprotein as antiviral target.