G蛋白家族参与心房颤动(简称房颤)中的信号转导,通过调控自主神经活性诱发和维持房颤。信号转导通路中Gα_(i/o)β_γ的作用至关重要,其可解离为Gα_(i/o)和Gβ_γ,引起窦房结和房室结传导延缓、心房有效不应期缩短及离散度增加,使房颤的诱发率增加。如能抑制其解离,即可干预房颤的发生和发展。 The G protein family is involved in signal transduction in atrial fibrillation (AF) and induces and maintains AF by regulating autonomic activity. The role of Gα_ (i / o) β_γ in the signal transduction pathway is of crucial importance. It can be dissociated into Gα_ (i / o) and Gβ_γ, causing delayed conduction of the sinus node and atrioventricular node, shortening of effective atrial refractory period and Discrepancy increases, the induction rate of atrial fibrillation increased. If it can inhibit the dissociation, you can interfere with the occurrence and development of atrial fibrillation.