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目前,越来越多的研究表明Celltracks(R) AutoPrep(R)系统会漏检非典型上皮特性的循环肿瘤细胞(CTCs),这部分CTCs比单纯表达上皮特性的CTCs具有更强的侵袭和转移能力,对患者的疗效和预后判断具有更高的价值.本文主要综述Celltracks(R) AutoPrep(R)系统与ISET技术的对比研究及EpCAM表达、混合肿瘤细胞、上皮间质转化(EMT)肿瘤细胞、循环肿瘤干细胞和不可逆EMT+肿瘤细胞对Celltracks(R) AutoPrep(R)系统检出率的影响,分析Celltracks(R)AutoPrep(R)系统检测CTCs的可行性.“,”At present, more and more research indicates that Celltracks(R) AutoPrep(R) misses circulating tumor cells(CTCs)with atypicalepithelial characteristics,which have a stronger ability of invasion and metastasis than CTCs simply expressing epithelial characteristic and a higher value to judge efficacy and prognosis. This paper reviews the contrast between Celltracks AutoPrep system and ISET technology,and the effect of EpCAM expression, hybrid,EMT+tumor,circulating tumor stem cells and irreversible EMT+tumor cells on the detection rate of Celltracks(R) AutoPrep(R)system,as well as the feasibility of Celltracks(R) AutoPrep(R) system for detecting CTCs.