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目的 检测医用纳米级Fe3 O4磁流体的急性毒性 ,为进一步研究其长期毒性以及载附药物的临床试验打下基础。方法 按不同浓度不同容积分别通过口服法、静脉注射法及腹腔注射法给予小鼠医用纳米级Fe3 O4磁流体 ,观察小鼠的急性毒性反应和主要脏器的病理学改变。结果 小鼠口服半数致死剂量LD50 >2 10 4 8mg/kg ,最大无毒性剂量ED0 为 32 0 10mg/kg ;静脉注射LD50 >4 38 5 0mg/kg ,ED0 为 16 0 0 5mg/kg ;腹腔注射LD50 >15 78 6mg/kg ,ED0 为 32 0 10mg/kg。主要脏器未见明显病理改变。 结论 医用纳米级Fe3 O4磁流体在动物体内的急性毒性很低 ,可以考虑作为药物载体。
Objective To detect the acute toxicity of medical nanoscale Fe3 O4 magnetic fluid, and lay the foundation for further study of its long-term toxicity and drug-loaded clinical trials. Methods The mice were given medical Fe3O4 magnetic fluid by oral administration, intravenous injection and intraperitoneal injection at different volumes and volumes respectively. The acute toxicity and the pathological changes of the organs were observed. Results The LD50> 2 1048mg / kg, the maximum nontoxic dose ED0 was 32 0 10mg / kg, the LD50> 4358mg / kg, ED0 16 0 05mg / kg, and the intraperitoneal injection LD50> 15 78 6 mg / kg, ED0 32 0 10 mg / kg. No significant pathological changes in the main organs. Conclusion Medical nanometer Fe3 O4 magnetic fluid has very low acute toxicity in animal and can be considered as drug carrier.