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口腔病灶被证实与许多系统性疾病的发生及发展有很大的相关关系,全身系统性疾病的治疗又会加重口腔病灶的感染,影响患者的生存质量,干扰系统性疾病的治疗,严重则造成全身感染。可能诱发或加重口腔病灶感染的系统性疾病治疗有:口服抗癫痫药物、免疫抑制剂等药物导致的药物性牙龈炎;恶性肿瘤放化疗并发的口腔黏膜炎;长期应用抑制肿瘤骨转移或预防骨质疏松的双磷酸盐造成的颌骨坏死;异基因造血干细胞移植后的口腔排异反应等。
Oral lesions have been shown to be associated with the development and progression of many systemic diseases. The treatment of systemic diseases aggravates the infection of oral lesions, affects the quality of life of patients, interferes with the treatment of systemic diseases, and causes severe Systemic infection. Treatment of systemic diseases that may induce or aggravate oral lesions include: drug-induced gingivitis caused by drugs such as oral antiepileptic drugs and immunosuppressive agents; oral mucositis associated with radiotherapy and chemotherapy of malignant tumors; long-term use of drugs that inhibit tumor bone metastases or prevent bone formation Osteoporosis osteoporosis caused by osteoporosis; oral rejection after allogeneic hematopoietic stem cell transplantation.