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目的探讨三维适形放疗联合同期化疗治疗中晚期食管癌的临床疗效。方法将86例中晚期食管癌患者随机分为观察组(47例)和对照组(39例),观察组给予三维适形放疗联合同期化疗,对照组患者给予单纯三维适形放疗治疗。结果观察组与对照组完全缓解率分别为63.83%(30/47)和41.03%(16/39),有效率分别为91.49%(43/47)和71.79%(28/39),观察组显著高于对照组(P<0.05)。观察组和对照组1年局部控制率、1年生存率分别是89.36%(42/47)、71.79%(28/39)和82.98%(39/47)、64.10%(25/39),观察组显著高于对照组(P<0.05)。结论采用三维适形放疗联合同期化疗治疗中晚期食管癌的近期疗效和局部控制率较好,值得临床推广并进一步深入研究。
Objective To investigate the clinical efficacy of three-dimensional conformal radiotherapy combined with concurrent chemotherapy in the treatment of advanced esophageal cancer. Methods Eighty-six patients with advanced esophageal cancer were randomly divided into observation group (n = 47) and control group (n = 39). The observation group received three-dimensional conformal radiotherapy combined with concurrent chemotherapy and the control group received simple three-dimensional conformal radiotherapy. Results The complete remission rates of the observation group and the control group were 63.83% (30/47) and 41.03% (16/39), respectively. The effective rates were 91.49% (43/47) and 71.79% (28/39) respectively. The observation group was significantly Higher than the control group (P <0.05). The 1-year local control rate and 1-year survival rate were 89.36% (42/47), 71.79% (28/39), 82.98% (39/47) and 64.10% (25/39) in the observation group and the control group, respectively Group was significantly higher than the control group (P <0.05). Conclusion The three-dimensional conformal radiotherapy combined with concurrent chemotherapy for the treatment of advanced esophageal cancer, the short-term efficacy and local control rate is good, worthy of clinical promotion and further study.