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目的:探讨重度抑郁症患者嗜睡症状与快感缺失的相关性。方法:2018年11月至2019年5月，以符合ICD-10诊断标准的重度抑郁症住院患者为研究对象，根据Epworth嗜睡量表(Epworth sleepiness scale，ESS)，将ESS≥7分定为白天嗜睡组，共纳入46例；将ESS<7分定为无嗜睡组，共纳入171例。采用中文版修订社会快感缺失量表(revised social anhedonia scale，RSAS)、中文版修订躯体快感缺失量表(revised physical anhedonia scale，RPAS)评估患者的快感缺失症状，采用双因素方差分析、Pearson相关分析进行数据处理。结果:(1)有无嗜睡和性别对躯体快感缺失得分的影响不存在交互作用(n F＝0.274，n P＝0.601)，主效应分析提示性别对躯体快感缺失的影响差异有统计学意义(n F＝10.948，n P<0.05)。(2)有无嗜睡和年龄对躯体快感缺失得分的影响存在交互作用(n F＝4.396，n P＝0.013)，进一步做简单效应分析，在白天嗜睡组中，40～49年龄段的患者躯体快感缺失得分[(21.54±12.37)分]低于50～64岁年龄段[(34.13±12.53)分](n P<0.05)。(3)有无嗜睡和坐躺时间对社会快感缺失得分的影响存在交互作用(n F＝4.247，n P＝0.041)，进一步做简单效应分析，在白天嗜睡组中，坐躺时间<2 h的患者社会快感缺失得分[(13.71±5.18)分]低于坐躺时间≥2 h的患者[(19.75±6.39)分](n P<0.05)。(4)Pearson相关分析结果显示，抑郁症患者嗜睡总分与社会快感缺失得分呈正相关(n r＝0.206，n P<0.01)，在调整了性别、年龄及坐躺时间后嗜睡总分仍与社会快感缺失得分呈显著正相关(n r＝0.225，n P<0.01)。n 结论:重度抑郁症患者日间嗜睡症状与快感缺失相关联。“,”Objective:To explore the correlation between hypersomnia and anhedonia in patients with major depressive disorder.Methods:From November 2018 to May 2019, patients hospitalized with major depressive disorder who met the ICD-10 diagnostic criteria were selected.According to the Epworth Sleepiness Scale (ESS), 46 patients were divided into daytime sleepiness group with ESS ≥ 7, and 171 patients were divided into non-sleepiness group with ESS < 7.The Chinese Revised Social Anhedonia Scale (RSAS) and the Chinese Revised Physical Anhedonia Scale (RPAS) were used to evaluate the patients' anhedonia symptoms.Two-way ANOVA and Pearson correlation analysis were used for data processing.Results:(1)There was no interaction between the hypersomnia and gender on the score of physical anhedonia (n F=0.274, n P=0.601). The main effect analysis showed that there was significant difference in the influence of gender on physical anhedonia (n F=10.948, n P<0.05). (2)There was interaction between the hypersomnia and age on the score of physical anhedonia (n F=4.396, n P=0.013). Further simple effect analysis showed that the score of physical anhedonia in 40-49 age(21.54±12.37) was lower than that in 50-64 age(34.13±12.53) in daytime sleepiness group(n P<0.05). (3) There was interaction between hypersomnia and sitting and lying on the score of social anhedonia (n F=4.247, n P=0.041). Further simple effect analysis showed that the score of social anhedonia in patients with sitting and lying time less than 2 hours (13.71±5.18) was lower than that in patients with sitting and lying time more than 2 hours (19.75±6.39) in daytime sleepiness group(n P<0.05). (4)Pearson correlation analysis showed that the total sleepiness score of depression patients was positively correlated with the social anhedonia score (n r=0.206, n P<0.01). After adjusting for gender, age and sitting and lying time, the total sleepiness score was still positively correlated with the social anhedonia score(n r=0.225, n P<0.01).n Conclusion:Hypersomnia may be associated with anhedonia in patients with major depressive disorder.