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目的研究分析为非酒精性脂肪肝患者(NAFLD)施以二甲双胍与水飞蓟宾联合治疗的效果。方法在河南能源鹤煤总医院实行治疗的NAFLD患者中选取68例作为研究对象,分为a、b两组,各34例。使用二甲双胍与水飞蓟宾为a组患者实行联合治疗,单独使用水飞蓟宾为b组患者实行治疗,对比两组患者治疗前后γ-谷氨酰转移酶(γ-GT)、谷转氨酶(AST)、谷丙转氨酶(ALT)等肝功能指标的变化情况,以及治疗效果。结果治疗前,两组患者的γ-GT、AST、ALT等肝功能指标,组间对比差异较小(P>0.05)。治疗后,a组患者治疗总有效率(85.%)远远高于b组患者;γ-GT、AST、ALT等肝功能指标改善情况优于b组患者,以上对比差异均明显(P<0.05)。结论在NAFLD患者临床治疗方面,使用二甲双胍与水飞蓟宾联合治疗,治疗效果显著,值得推广。
Objective To study the effect of combination therapy with metformin and silybin in patients with non-alcoholic fatty liver disease (NAFLD). Methods A total of 68 NAFLD patients treated by Henan Heyuan Coal General Hospital were enrolled in this study. The patients were divided into two groups a and b, with 34 cases in each group. Treatment with metformin and silybin for a group of patients with combination therapy, silybin alone for the treatment of patients in group b, compared two groups of patients before and after treatment γ-glutamyl transferase (γ-GT), transaminase ( AST), alanine aminotransferase (ALT) and other indicators of liver function changes, and the treatment effect. Results Before treatment, the liver function indexes such as γ-GT, AST and ALT in both groups showed no significant difference (P> 0.05). After treatment, the total effective rate of treatment in group A was much higher than that in group b (85%). The improvement of liver function indexes such as γ-GT, AST and ALT were superior to those in group b, the difference was significant (P < 0.05). Conclusion In the clinical treatment of patients with NAFLD, the combination of metformin and silybin has a significant therapeutic effect and is worthy of promotion.