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本文采用睡前单剂口服甲氰眯胺预防溃疡复发,以双盲法观察6个月,定期做内窥镜检查。病例和方法:55例成人门诊患者参加试验,均为已用甲氰咪胺(400mg)或安慰剂每日4次治疗的活动性十二指肠溃疡患者。随机分为甲氰咪胺(800mg)和安慰剂二组,两组性别、年龄和溃疡病程相似。停用其他一切抗溃疡药物,每月随访1次,治疗后6周、3个月和6个月时重复内窥镜检查,用X~2试验比较两组患者溃疡复发率和疼痛发生率。结果:55例中有45例完成6个月试验。甲氰咪胺组和安慰剂组在治疗后6周内窥镜检查无溃疡的例数分别为19(90%)和8(33%),在3个月检查分别为17(81%)和3(12.5%),在6个月检查分别为16(76%)和3(12.5%),均有统计学上的显著差异(P<0.0005)。副作用:除安慰剂组1例体重减轻停药外,未见因治疗引起的症状而停止试验。两组中各有1例便秘、1例头痛和疲劳。治疗组1例因心悸在完成试验后停药。
In this paper, a single dose of propranolol at bedtime to prevent recurrence of ulcer, double-blind observation of 6 months, regular endoscopic examination. Cases and Methods: Fifty-five adult outpatients participated in the trial, all of whom had active duodenal ulcer patients who had been treated with either Cimetidine (400 mg) or placebo 4 times daily. Randomly divided into cimetidine (800mg) and placebo two groups, two groups of similar gender, age and ulcer disease. All other anti-ulcer drugs were discontinued, once per month, endoscopy was repeated at 6 weeks, 3 months and 6 months after treatment. The incidence of ulcer recurrence and pain were compared between two groups by X ~ 2 test. RESULTS: Forty-five of 55 patients completed the 6-month trial. The number of endoscopic non-ulcer endoscopy was 19 (90%) and 8 (33%) in cidadrine and placebo groups, respectively, and 17 (81%) at 3 months and 3 (12.5%), with 16 (76%) and 3 (12.5%) at 6 months, respectively, with statistically significant differences (P <0.0005). Side effects: In addition to the placebo group of 1 weight loss withdrawal, no symptoms due to treatment and stop the test. One case of constipation, one case of headache and fatigue in both groups. One patient in the treatment group discontinued after completing the test due to heart palpitations.