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目的了解呼吸道病原体Ig M抗体联合检测在呼吸道感染诊断中的作用。方法选取1 236例呼吸道感染患者,分别抽取患者外周静脉血采用间接免疫荧光法检测肺炎支原体、肺炎衣原体、乙型流感病毒、甲型流感病毒、腺病毒、副流感病毒、Q热立克次体、呼吸道合胞病毒以及嗜肺军团菌等9种常见的呼吸道病原体的Ig M抗体。结果 1 236例患者496例为病原体Ig M抗体阳性,阳性率为40.1%;MP、CP、IBV、IAV、ADV、PIV、QFR、RSV和LP等9种病原体Ig M抗体检出率分别为275(22.24%)、11(0.89%)、69(5.58%)、37(2.99%)、14(1.13%)、40(3.24%)、17(1.38%)、18(1.46%)、15(1.2%);340(68.55%)例为单一病原体感染,另外156(31.45%)例为混合感染,其中145(92.95%)例为二重感染,11(7.05%)例为三重感染;小于18岁、18~50岁和50岁以上患者病原体Ig M抗体阳性率分别为59.29%、16.89%和32.88%,两两之间相比差异具有统计学意义(P<0.05)。结论呼吸道病原体Ig M抗体联合检测能够准确判别患者病原体的感染类型,对于呼吸道感染患者的诊断和治疗均具有指导作用。
Objective To understand the role of respiratory tract antigen IgM antibody in the diagnosis of respiratory tract infection. Methods A total of 1,236 patients with respiratory tract infection were selected. Peripheral venous blood was collected from patients for detecting Mycoplasma pneumoniae, Chlamydia pneumoniae, Influenzavirus B, Influenza A, Adenovirus, Parainfluenza virus, , Respiratory syncytial virus and Legionella pneumophila and other 9 kinds of common respiratory pathogens Ig M antibodies. Results A total of 496 cases were positive for pathogen IgM in 1 236 cases, and the positive rate was 40.1%. The detection rates of IgM antibodies against 9 pathogens including MP, CP, IBV, IAV, ADV, PIV, QFR, RSV and LP were 275 (22.24 percent), 11 (0.89 percent), 69 (5.58 percent), 37 (2.99 percent), 14 (1.13 percent), 40 (3.24 percent), 17 (1.38 percent), 18 %); 340 (68.55%) cases were single-pathogen infection, while 156 (31.45%) cases were mixed infection, of which 145 (92.95%) were double infection and 11 The positive rates of IgM antibodies of pathogens in patients aged 18-50 years and over 50 years were 59.29%, 16.89% and 32.88%, respectively. There was significant difference between them (P <0.05). Conclusion The combined detection of respiratory tract IgM antibodies can accurately identify the type of infection in patients with pathogens, which can guide the diagnosis and treatment of patients with respiratory tract infections.