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茶碱类药物用于治疗哮喘已有 50多年的历史 ,为世界范围内应用最广泛的抗哮喘药物 ,至今许多国家和地区仍将茶碱作为第一线平喘药物应用于临床[1 ] 。茶碱类药物的血药浓度超过治疗水平 (2 0ｍｇ·Ｌ 1 以上 )时 ,易发生不良反应[1 ] ;茶碱与其他药物合用可影响其血药浓度。1
Theophylline has been used in the treatment of asthma for more than 50 years and is the most widely used anti-asthma drug in the world. Theophylline is still the first-line antiasthmatic drug used in clinical practice in many countries and regions so far [1]. Theophylline drug plasma concentration exceeds the therapeutic level (20mg · L 1 above), prone to adverse reactions [1]; theophylline and other drugs can affect its plasma concentration. 1