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胆汁淤积(cholestasis)是指胆汁生成和(或)胆汁流动障碍所致的临床和生化异常综合征,临床表现主要为黄疸、瘙痒和疲劳[1],生化异常主要是血总胆红素(TB)及碱性磷酸酶(ALP)升高。胆汁淤积可因病理损伤分为肝内及肝外两大类,肝内胆汁淤积也可称为胆汁淤积性肝病,由于其病因复杂,临床诊断常较困难。胆汁淤积性肝病的病因一、炎症各种炎症过程可干扰肝细胞摄取胆红素、排泌胆汁的功能,也常损毁肝内小胆管,是胆汁淤积性肝病常见的一大类原因。1.病毒性肝炎:甲型病毒性肝炎(甲肝)、乙型病毒性肝
Cholestasis refers to clinical and biochemical abnormalities caused by bile production and / or bile flow disorders. The main clinical manifestations are jaundice, pruritus and fatigue [1], and biochemical abnormalities are mainly blood total bilirubin (TB ) And alkaline phosphatase (ALP) increased. Cholestasis can be divided into two categories of intrahepatic and extrahepatic lesions due to pathological damage, intrahepatic cholestasis can also be called cholestatic liver disease, due to its etiology, clinical diagnosis is often more difficult. The causes of cholestatic liver disease First, inflammation Inflammation process can interfere with liver cells uptake of bilirubin, excretion of bile function, but also often damage the intrahepatic bile duct is a common cause of cholestatic liver disease. 1. Viral hepatitis: A viral hepatitis (hepatitis A), hepatitis B virus