在五十年代初期发现了一组大环内酯类抗生素,它们的组成是由一个大的环状内酯环和糖类相连。红霉素是于1952年由印第安纳波利斯 Lilly 研究实验室的 Mcguire 等发现的第一个大环内酯抗生素。该化合物是由菲律宾土样中获得的一株红霉素链霉菌所产生,1960年 Abraham&Newton 测定了它的结构。红霉素作为抗细菌药物用于临床,主要抗革蓝氏阳性菌如肺炎球菌,链球菌和葡萄球菌,并把它当作是青霉素过敏患者的一个 In the early 1950s a group of macrolide antibiotics was discovered whose composition consisted of a large cyclic lactone ring linked to sugars. Erythromycin was the first macrolide antibiotic discovered in 1952 by McGuire and others at Lilly Research Laboratories in Indianapolis. The compound was produced by a strain of Streptomyces erythromycin obtained from a Philippine soil sample. Abraham & Newton determined its structure in 1960. Erythromycin is used clinically as an anti-bacterial drug, mainly against gram-positive bacteria such as pneumococcal, streptococcal and staphylococcal and treats it as a penicillin-allergic patient