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目的 观察溃疡性结肠炎患者血浆P -选择素的水平 ,并探讨其临床意义。方法 采用ELISA方法检测 2 8例溃疡性结肠炎活动期患者和 13例缓解期患者血浆P -选择素的含量。结果 溃疡性结肠炎活动期患者血浆P -选择素的含量与正常对照组和溃疡性结肠炎缓解期组比较差异均具有显著性意义 (P <0 0 1) ,而缓解期组与正常对照组之间无显著性差异。活动期组患者血浆P -选择素的含量与病情的严重程度呈正相关。结论 P -选择素参与溃疡性结肠炎的发病 ,检测P -选择素对溃疡性结肠炎的病情及疗效评估具有一定的参考价值
Objective To observe the plasma P - selectin level in patients with ulcerative colitis and to explore its clinical significance. Methods The plasma levels of P - selectin in 28 active ulcerative colitis patients and 13 remission patients were detected by ELISA. Results The plasma levels of P - selectin in active ulcerative colitis patients were significantly different from those in normal control group and ulcerative colitis remission group (P <0.01), while those in remission group were significantly higher than those in normal control group No significant difference between. The activity of plasma P - selectin in patients with the severity of the disease was positively correlated. Conclusions P - selectin is involved in the pathogenesis of ulcerative colitis and has certain reference value for the detection of P - selectin on the condition of ulcerative colitis and evaluation of curative effect