棉酚是对雄性具有抗生育效应的药物,早在三十年前我国就曾报道食用棉油导致不育,后来发现其有效成份为棉酚,并作为男性避孕药试用于临床。有关棉酚的抗生育作用机理已引起重视,并证实棉酚能破坏精子的结构,抑制精子的活动。值得注意的是棉酚存在着一定的毒副作用,据报道极少数个体在长期服用棉酚后,会出现低血钾肌无力症,其产生的原因尚未查明,据推测可能是Na,K-ATP酶受到抑制所致。毕晓峰等观测到棉酚对大鼠、豚鼠等肾皮质的Na,K-ATP酶有抑制作用,但符云峰等在家兔及大鼠肾皮质材料的实验中所得结果是棉酚对Mg-ATP酶有抑制作用,对Na,K-ATP酶无明显影响。因此,棉酚产生低钾的原因有待进一步澄清。 Gossypol is a drug that has anti-fertility effects on males. As early as thirty years ago, it was reported in our country that consumption of cottonseed oil resulted in infertility. Later, the active ingredient was found to be gossypol, and was tested as a male contraceptive in clinical trials. The mechanism of anti-fertility of gossypol has attracted attention, and confirmed that gossypol can destroy the structure of sperm, inhibit sperm activity. It is noteworthy that there is some gossypol side effects, it is reported that a very small number of individuals in the long-term use of gossypol, there will be hypokalemia, its causes have not yet been identified, presumably may be Na, K- ATPase is inhibited. Bi Xiaofeng and other observations of gossypol on rat, guinea pig and other renal cortex Na, K-ATPase inhibition, but Fu Yunfeng other rabbit and rat renal cortical material in the experiment results obtained gossypol on Mg-ATPase Have inhibitory effect on Na, K-ATPase no significant effect. Therefore, gossypol low potassium causes for further clarification.