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患者,女,61岁,冠心病患者,既往无血小板减少性紫癜病史。于1989年3月5日因胸闷、心悸、乏力3天就诊,心电图示频发室性早搏,即用胺碘酮(天津市中央制药二厂,批号870401)治疗,第1周剂量600mg/d,第2周剂量400mg/d。服药至第13天,鼻衄,齿龈出血,全身皮肤粘膜出现弥漫性淤点、淤斑。体检余无异常。心电图ⅡⅢ avF导联ST段下降0.4mv,无心律失常。化验,血细胞计数除血小板减少为4.7/μl外,余均正常。停用胺碘酮。用强的松45mg/d治疗,14天后血小板上升至17.5万,2个月后复查血小板18万。3个月后因再次发作频发性室性早搏,复用胺碘酮,10天后血小板
Patient, female, 61 years old, with coronary heart disease, previous history of thrombocytopenic purpura. March 5, 1989 due to chest tightness, palpitations, fatigue three days of treatment, ECG frequent premature ventricular contractions that amiodarone (Tianjin Central Pharmaceutical Factory, batch number 870401) treatment, the first week of dose 600mg / d , The second week dose 400mg / d. To the first 13 days of medication, epistaxis, gingival bleeding, mucocutaneous systemic mucosal diffuse deposition, ecchymosis. No abnormal physical examination. ECG Ⅱ Ⅲ avF lead ST segment decreased 0.4mv, no arrhythmia. Laboratory, blood count in addition to thrombocytopenia 4.7 / μl, the remaining were normal. Amiodarone discontinued. With prednisone 45mg / d treatment, 14 days after the platelet rose to 175000, 2 months after the review platelet 180,000. 3 months later due to recurrent episodes of frequent ventricular premature beats, amiodarone reuse, 10 days after platelet