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目的探讨乳腺浸润性导管癌钙化与人表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)及细胞增殖抗原Ki67间的关系。方法术前穿刺活检或术中冰冻组织病理证实乳腺浸润性导管癌者237例,术后均常规行免疫组织化学检查,依据术前钼靶X线将患者分为钙化组和无钙化组,比较2组HER-2、Ki67阳性表达率;分析不同钙化形态、分布及有无肿块者乳腺癌组织中HER-2、Ki67阳性表达率。结果237例中HER-2阳性表达率为56.12%,Ki67阳性表达率为67.93%;钼靶X线显示乳腺钙化者98例,无钙化者139例;钙化组HER-2阳性表达率(64.29%)高于无钙化组(50.36%),Ki67阳性表达率(53.06%)低于无钙化组(78.42%),差异均有统计学意义(P<0.05);泥砂样钙化组、蠕虫样钙化组、其他钙化组HER-2阳性表达率分别为62.32%、85.71%及25.00%、Ki67阳性表达率分别为63.77%、23.81%及37.50%,3组间比较差异有统计学意义(P<0.05);钙化灶弥漫、区段、成簇分布者HER-2、Ki67表达阳性率比较差异无统计学意义(P>0.05);钙化伴肿块者与未伴肿块者HER-2、Ki67表达阳性率比较差异无统计学意义(P>0.05)。结论乳腺浸润性导管癌组织HER-2、Ki67阳性表达率与病灶钙化及钙化灶形态有关。
Objective To investigate the relationship between calcification of breast invasive ductal carcinoma and human epidermal growth factor receptor-2 (HER-2) and cell proliferation antigen Ki67. Methods Preoperative biopsy or intraoperative frozen histopathology confirmed breast infiltrating ductal carcinoma in 237 cases, postoperative routine immunohistochemical examination according to preoperative molybdenum target X-ray patients were divided into calcification group and non-calcification group, compared The positive expression rates of HER-2 and Ki67 in 2 groups were analyzed. The positive rates of HER-2 and Ki67 in breast cancer tissues with different calcification, distribution and mass were analyzed. Results The positive rate of HER-2 was 56.12% and the positive rate of Ki67 was 67.93% in 237 cases. The positive rate of HER-2 in calcification group was 64.29% ) Was higher than that of no calcification group (50.36%), the positive rate of Ki67 expression was lower (53.06%) than that of no calcification group (78.42%), the differences were statistically significant (P <0.05) . The positive expression rates of HER-2 in other calcifications group were 62.32%, 85.71% and 25.00%, respectively. The positive rate of Ki67 expression was 63.77%, 23.81% and 37.50%, respectively. There was significant difference between the three groups (P <0.05) There was no significant difference in the positive rates of HER-2 and Ki67 in diffuse, segmental and clustered calcifications (P> 0.05). The positive rates of HER-2 and Ki67 in calcified patients with mass and non-mass The difference was not statistically significant (P> 0.05). Conclusion The positive rates of HER-2 and Ki67 in breast invasive ductal carcinoma are related to the lesions calcification and calcification.