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目的:探讨用CO2激光联合α-2b干扰素治疗尖锐湿疣的临床效果。方法:对2009年12月～2012年12月期间在我院皮肤性病科进行治疗的86例尖锐湿疣患者的临床资料进行回顾性研究。我们将这86例患者随机分为治疗组和对照组,每组各有43例患者。我们给对照组患者使用CO2激光进行治疗,给治疗组患者在使用CO2激光治疗(方法与对照组患者相同)的基础上,加用α-2b干扰素进行治疗。治疗结束后,比较两组患者的治疗效果。结果:治疗结束后,在治疗组的43例患者中,治疗结果为痊愈者有38例,治疗结果为有效者有3例,治疗结果为无效者有2例,治疗的总有效率为95.3%。在对照组的43例患者中,治疗结果为痊愈者有28例,治疗结果为有效者有5例,治疗结果为无效者有10例,治疗的总有效率为76.7%。治疗组患者治疗的总有效率明显高于对照组患者,二者相比差异具有显著性(P<0.05)。此外,在治疗期间,两组患者均未出现严重的不良反应,二者相比差异无显著性(P>0.05)。结论:用CO2激光联合α-2b干扰素治疗尖锐湿疣疗效显著,不良反应少。此疗法值得在临床上推广使用。
Objective: To investigate the clinical effect of CO2 laser combined with α-2b interferon on condyloma acuminatum. Methods: The clinical data of 86 patients with condyloma acuminatum who were treated in Department of Dermatology of our hospital from December 2009 to December 2012 were analyzed retrospectively. We randomly divided the 86 patients into treatment and control groups, each with 43 patients in each group. The control group of patients treated with CO2 laser treatment, the treatment group patients using CO2 laser treatment (the same method as the control group patients), plus interferon α2b treatment. After treatment, the treatment effect of two groups of patients was compared. Results: At the end of treatment, 38 out of 43 patients in the treatment group were cured, 3 were effective, 3 were ineffective, 2 were ineffective, and the overall response rate was 95.3% . Of the 43 patients in the control group, 28 were cured, 5 were effective, 5 were ineffective, and 76.7% were treated. The total effective rate of the treatment group was significantly higher than that of the control group, the difference was significant (P <0.05). In addition, during the treatment, no serious adverse reactions occurred in both groups, with no significant difference between the two groups (P> 0.05). Conclusion: The treatment of condylomata acuminatum with CO2 laser combined with interferon alfa-2b has obvious effect and few adverse reactions. This therapy is worth promoting in clinic.