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目的评价乌司他丁对重症监护病房(ICU)系统性炎症反应综合征(SIRS)患者的疗效。方法将78例系统性炎症反应综合征患者随机分为治疗组和对照组。对照组采用常规方法治疗,治疗组在其基础上加用乌司他丁。两组均以5 d为1个疗程。对比两组体温、心率、呼吸频率、白细胞计数、SIRS症状改善时间及住ICU时间。结果 1个疗程后治疗组体温、心率、呼吸频率、白细胞计数、SIRS症状改善时间及住ICU时间均优于对照组,差异均有统计学意义(P<0.05)。结论乌司他丁对ICU系统性炎症反应综合征患者有明显疗效。
Objective To evaluate the efficacy of ulinastatin in intensive care unit (ICU) patients with systemic inflammatory response syndrome (SIRS). Methods 78 patients with systemic inflammatory response syndrome were randomly divided into treatment group and control group. The control group was treated by conventional method, and the treatment group was given ulinastatin on the basis of it. Both groups took 5 days as a course of treatment. The body temperature, heart rate, respiratory rate, white blood cell count, SIRS symptom improvement time and ICU time were compared between the two groups. Results After 1 course of treatment, body temperature, heart rate, respiratory rate, white blood cell count, SIRS symptom improvement and ICU stay in the treatment group were all better than those in the control group (P <0.05). Conclusion Ulinastatin has a significant effect on ICU patients with systemic inflammatory response syndrome.