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用免疫细胞化学染色法观察抗纤复方药物血清对大鼠正常肝传代贮脂细胞和纤维肝原代贮脂细胞Ⅰ、Ⅲ型胶原表达的影响,并对Ⅰ型和Ⅲ型胶原的表达量进行比较分析。结果:传代贮脂细胞Ⅲ型胶原增加显著,而纤维肝贮脂细胞Ⅰ型胶原增加明显,抗纤复方能显著抑制贮脂细胞表达胶原,且对传代贮脂细胞Ⅲ型胶原和纤维肝原代贮脂细胞Ⅰ型胶原抑制作用更明显。
To observe the effect of anti-fibrosis compound drug serum on the expression of type I and type III collagen in rats’ normal liver-passage-storage fat cells and fibrotic liver primary lipid-storage cells by immunocytochemistry staining, and to express the expression levels of type I and type III collagen. comparative analysis. RESULTS: Type III collagen was significantly increased in passaged fat-storing cells, while type I collagen was significantly increased in fibroblasts. Anti-fibrosis compound can significantly inhibit the expression of collagen in fat-storing cells, and it also protects type III collagen and fibroblasts in passaged fat-storing cells. The inhibitory effect of type I collagen in lipid-storing cells is more pronounced.