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目的探讨高尿酸血症患者尿酸水平与视网膜动脉硬化的关系。方法选择济南市第二人民医院健康查体者中高尿酸血症145例,同期健康查体者中血尿酸正常者150例为对照组,观察视网膜动脉硬化程度,并采用颈动脉多普勒超声检测颈动脉硬化程度。结果高尿酸血症组视网膜动脉硬化及患病率明显高于对照组(P<0.05),血尿酸与视网膜动脉硬化程度呈正相关(r=0.893,P<0.05)。各级视网膜动脉硬化与同级颈动脉硬化之间血尿酸值无明显差异。结论高尿酸血症导致的大血管硬化程度与视网膜动脉硬化程度高度一致。眼底检查作为简便易行的全身动脉硬化检查方法,可早期对血尿酸进行干预,以预防心脑血管事件的发生。
Objective To investigate the relationship between uric acid and retinal arteriosclerosis in patients with hyperuricemia. Methods 145 cases of hyperuricemia in health checkup of Second People’s Hospital of Jinan City and 145 cases of normal blood uric acid in healthy checkup were selected as control group. The degree of retinal atherosclerosis was observed. The carotid artery Doppler echocardiography Carotid atherosclerosis. Results The incidence of retinal atherosclerosis and prevalence in hyperuricemia group was significantly higher than that in control group (P <0.05). There was a positive correlation between serum uric acid and retinal atherosclerosis (r = 0.893, P <0.05). There was no significant difference in serum uric acid between retinal arteriosclerosis at all levels and atherosclerotic carotid atherosclerosis. Conclusions The degree of macrovascular stiffness induced by hyperuricemia is highly consistent with the degree of retinal atherosclerosis. Fundus examination as a simple and easy method of systemic arteriosclerosis can be early intervention of serum uric acid to prevent cardiovascular events.