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乙型肝炎病毒感染对患者发展为肝硬化和肝细胞癌起重要作用。乙型肝炎病毒导致肝癌的发病机理尚未完全阐明。有些证据表明乙型肝炎病毒X蛋白在肝癌发病机制中起关键作用。该文综述了乙型肝炎病毒X蛋白导致肝细胞癌变的各种机理。
Hepatitis B virus infection plays an important role in the development of cirrhosis and hepatocellular carcinoma in patients. The pathogenesis of hepatocellular carcinoma caused by hepatitis B virus has not been fully elucidated. There is some evidence that hepatitis B virus X protein plays a key role in the pathogenesis of liver cancer. This paper reviews the various mechanisms by which hepatitis B virus X protein causes hepatocellular carcinoma.