应用化合物48/80诱发ddY小鼠瘙痒模型,研究了蛇床子70％乙醇提取物(CM-ext)的止痒作用及其活性成分。 材料与方法:①蛇床子(500g)碾碎后,用70％乙醇回流提取2次,每次1h。合并提取液,减压浓缩、冻干,得到棕色粉末CM-ext(37.7g,产率14.7％)。②CM-ext成分分离:CM-ext(53.7g)混 The pruritus model of ddY mice was induced with compound 48/80 to study the antipruritic effect of Cnidium monnieri 70% ethanol extract (CM-ext) and its active ingredients. Materials and Methods: 1 Cnidium (500g) was crushed and extracted twice with 70% ethanol for 1h each time. The extracts were combined, concentrated under reduced pressure, and lyophilized to give a brown powder CM-ext (37.7 g, yield 14.7%). 2CM-ext composition separation: CM-ext (53.7g) mixed